探索癌症

Multiple randomized studies have demonstrated improved response rates, progression-free survival, and quality of life for treatment-naive, advanced-stage adenocarcinoma patients harboring sensitizing EGFR mutations when they are treated with tyrosine kinase inhibitor therapy, as compared with chemotherapy. Despite improved outcomes with these agents, the majority of patients will eventually develop resistance and subsequent clinical progression. Recently, there has been a firmer understanding of the molecular mechanisms of the resistance that develops as a consequence of treatment, most notably the identification of a second-site EGFR mutation, T790M. While this understanding can inform subsequent treatment decisions, disease progression can be heterogeneous, and there are several competing therapeutic options. Treatment decisions must consider this clinical heterogeneity, factoring in the pace of disease growth, lung cancer–related symptoms, and the potential presence of T790M mutations. Herein, we review the available literature addressing these competing strategies and attempt to clarify best treatment practices, including the emerging role of T790M-directed therapies.

http://www.cancernetwork.com/oncology-journal/attacking-moving-target-understanding-resistance-and-managing-progression-egfr-positive-lung-cancer/page/0/1

http://www.chinatimes.com/newspapers/20141102000295-260102

高雄醫學大學研究發現，罹患肺癌的危險因子除了吸菸之外，肺結核患者、炒菜未使用抽油煙機及居住鄰近工業區的人都較易罹患肺癌，且吸菸者本身罹患鱗狀細胞或小細胞肺癌的機率高，吸二手菸者及油煙則較易罹患肺腺癌。

https://www.facebook.com/notes/ben-jei-tsuang/%E8%82%BA%E8%85%BA%E7%99%8C%E5%A2%9E%E5%8A%A0%E4%B9%8B%E5%8F%AF%E8%83%BD%E5%8E%9F%E5%9B%A0/397618533619840

http://cisc.twbbs.org/lib/addon.php?act=post&id=3075

環境污染是癌症節節上升的主要原因
尤其是不抽煙的女性 許多醫生學者歸究於女性基因對致癌物質易敏感性